| Function | Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. |
| Protein Name | Interleukin-12 Subunit BetaIl-12bCytotoxic Lymphocyte Maturation Factor 40 Kda SubunitClmf P40Il-12 Subunit P40Nk Cell Stimulatory Factor Chain 2Nksf2 |
| Database Links | Reactome: R-HSA-6783783Reactome: R-HSA-6785807Reactome: R-HSA-9020591Reactome: R-HSA-9020933 |
| Cellular Localisation | Secreted |
| Alternative Nanobody Names | Anti-Interleukin-12 Subunit Beta nanobodyAnti-Il-12b nanobodyAnti-Cytotoxic Lymphocyte Maturation Factor 40 Kda Subunit nanobodyAnti-Clmf P40 nanobodyAnti-Il-12 Subunit P40 nanobodyAnti-Nk Cell Stimulatory Factor Chain 2 nanobodyAnti-Nksf2 nanobodyAnti-IL12B nanobodyAnti-NKSF2 nanobody |
Information sourced from Uniprot.org
![Anti-IL12B/IL-12 p40/NKSF2 nanobody [SAA1159] (STJN000192)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200805/412987/STJN000192-SDS-PAGE-1__23413.1749232510.jpg?c=1 "Anti-IL12B/IL-12 p40/NKSF2 nanobody [SAA1159] (STJN000192)")
![Anti-IL12B/IL-12 p40/NKSF2 nanobody [SAA1159] (STJN000192)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200805/412987/STJN000192-SDS-PAGE-1__23413.1749232510.jpg?c=1 "Anti-IL12B/IL-12 p40/NKSF2 nanobody [SAA1159] (STJN000192)")
