Anti-IL12B antibody (23-328 aa) [S5033RM] (STJ11105033)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Interleukin-12 Subunit Beta (23-328 aa) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S5033RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IL12B |
| Gene ID | 3593 |
| Uniprot ID | IL12B_HUMAN |
| Immunogen Region | 23-328 aa |
| Immunogen Sequence | IWELKKDVYVVELDWYPDAP GEMVVLTCDTPEEDGITWTL DQSSEVLGSGKTLTIQVKEF GDAGQYTCHKGGEVLSHSLL LLHKKEDGIWSTDILKDQKE PKNKTFLRCEAKNYSGRFTC WWLTTISTDLTFSVKSSRGS SDPQGVTCGAATLSAERVRG DNKEYEYSVECQEDSACPAA EESLPIEVMVDAVHKLKYEN YTSSFFIRDIIKPDPPKNLQ LKPLKNSRQVEVSWEYPDT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 23-328 of human IL12. (NP_002178.2). |
Additional Info
| Post Translational Modifications | Known to be C-mannosylated in the recombinant protein.it is not yet known for sure if the wild-type protein is also modified. |
| Function | Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. |
| Protein Name | Interleukin-12 Subunit BetaIl-12bCytotoxic Lymphocyte Maturation Factor 40 Kda SubunitClmf P40Il-12 Subunit P40Nk Cell Stimulatory Factor Chain 2Nksf2 |
| Database Links | Reactome: R-HSA-6783783Reactome: R-HSA-6785807Reactome: R-HSA-9020591Reactome: R-HSA-9020933 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-12 Subunit Beta antibodyAnti-Il-12b antibodyAnti-Cytotoxic Lymphocyte Maturation Factor 40 Kda Subunit antibodyAnti-Clmf P40 antibodyAnti-Il-12 Subunit P40 antibodyAnti-Nk Cell Stimulatory Factor Chain 2 antibodyAnti-Nksf2 antibodyAnti-IL12B antibodyAnti-NKSF2 antibody |
Information sourced from Uniprot.org