Host: | Rabbit |
Applications: | ELISA/IHC/IP/WB |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-IL-34 is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Purification: | Affinity Purified |
Concentration: | 0.5-1.5 µg/µl |
Dilution Range: | WB: 1:500-1:5, 000 ELISA: 1:50, 000 IP: 1:200 IHC: 1:50-1:200 |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Gene Symbol: | IL34 |
Gene ID: | 146433 |
Uniprot ID: | IL34_HUMAN |
Immunogen: | Interleukin-34 |
Tissue Specificity | Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon. |
Function | Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. |
Protein Name | Interleukin-34 Il-34 |
Database Links | Reactome: R-HSA-449836 Reactome: R-HSA-9680350 |
Cellular Localisation | Secreted |
Alternative Antibody Names | Anti-Interleukin-34 antibody Anti-Il-34 antibody Anti-IL34 antibody Anti-C16orf77 antibody |
Information sourced from Uniprot.org