| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
SRM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
Il23r |
| Gene ID: |
209590 |
| Uniprot ID: |
IL23R_MOUSE |
| Immunogen Region: |
24-315 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 24-315 of mouse IL-23R (NP_653131.3). |
| Immunogen Sequence: |
GITSINCSGDMWVEPGEIFQ MGMNVSIYCQEALKHCRPRN LYFYKNGFKEEFDITRINRT TARIWYKGFSEPHAYMHCTA ECPGHFQETLICGKDISSGH PPDAPSNLTCVIYEYSGNMT CTWNTGKPTYIDTKYIVHVK SLETEEEQQYLASSYVKIST DSLQGSRKYLVWVQAVNSLG MENSQQLHVHLDDIVIPSAS IISRAETTNDTVPKTIVYWK SKTMIEKVFCEMRYKTTTN |
| Tissue Specificity | Expressed by Th1, Th2 and dendritic cells. |
| Post Translational Modifications | Phosphorylated in response to IL23. |
| Function | Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. |
| Protein Name | Interleukin-23 ReceptorIl-23 ReceptorIl-23r |
| Database Links | Reactome: R-MMU-9020933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-23 Receptor antibodyAnti-Il-23 Receptor antibodyAnti-Il-23r antibodyAnti-Il23r antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
