Anti-IL-10 antibody [JES3-9D7] {AF488} (STJA0004159)

SKU:
STJA0004159

£144.50 - £328.50
Current Stock:
Host: Rat
Applications: ICFC
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rat monoclonal antibody anti-Interleukin-10 is suitable for use in IConfocal MicroscopyC research applications.
Clonality: Monoclonal
Clone ID: JES3-9D7
Conjugation: AF488
Isotype: IgG1k
Formulation: PBS with 0.05% Proclin300, 1% BSA
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.
Gene Symbol: IL10
Gene ID: 3586
Uniprot ID: IL10_HUMAN
Tissue Specificity Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.
Function Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling.
Protein Name Interleukin-10
Il-10
Cytokine Synthesis Inhibitory Factor
Csif
Database Links Reactome: R-HSA-6783783
Reactome: R-HSA-6785807
Reactome: R-HSA-8950505
Reactome: R-HSA-9662834
Reactome: R-HSA-9664323
Cellular Localisation Secreted
Alternative Antibody Names Anti-Interleukin-10 antibody
Anti-Il-10 antibody
Anti-Cytokine Synthesis Inhibitory Factor antibody
Anti-Csif antibody
Anti-IL10 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance