| Host: | Mouse |
| Applications: | WB |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-IL-1 beta is suitable for use in Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | SM0498 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.15% ProClin300, 100 Mu g/mL BSA and 50% glycerol. |
| Purification: | Affinity purification |
| Dilution Range: | WB (M) 1:300-1:500 |
| Storage Instruction: | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
| Gene Symbol: | Il1b |
| Gene ID: | 16176 |
| Uniprot ID: | IL1B_MOUSE |
| Immunogen: | Recombinant protein corresponding to Mouse IL-1 beta |
| Function | Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. |
| Protein Name | Interleukin-1 Beta Il-1 Beta |
| Database Links | Reactome: R-MMU-448706 Reactome: -MMU-5620971 Reactome: -MMU-5660668 Reactome: -MMU-9020702 |
| Cellular Localisation | Cytoplasm Cytosol Secreted Lysosome Extracellular Exosome The Precursor Is Cytosolic In Response To Inflammasome-Activating Signals Such As Atp For Nlrp3 Inflammasome Or Bacterial Flagellin For Nlrc4 Inflammasome Cleaved And Secreted Mature Form Is Secreted And Released In The Extracellular Milieu By Passing Through The Gasdermin-D (Gsdmd) Pore In Contrast The Precursor Form Is Not Released Due To The Presence Of An Acidic Region That Is Proteolytically Removed By Casp1 During Maturation The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10 |
| Alternative Antibody Names | Anti-Interleukin-1 Beta antibody Anti-Il-1 Beta antibody Anti-Il1b antibody |
Information sourced from Uniprot.org