Anti-IKB epsilon antibody [R05-1B2] (STJA0035235)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human IKB epsilon
General Information
| Short Description | Rabbit monoclonal anti-IKB epsilon for use in WB and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IP |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R05-1B2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | NFKBIE |
| Gene ID | 4794 |
| Uniprot ID | IKBE_HUMAN |
| Immunogen | A synthetic peptide of human IKB epsilon |
Additional Info
| Tissue Specificity | Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages. |
| Post Translational Modifications | Serine phosphorylated.followed by proteasome-dependent degradation. |
| Function | Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity. Sequestered complexes include NFKB1-RELA (p50-p65) and NFKB1-REL (p50-c-Rel) complexes. Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development. |
| Protein Name | Nf-Kappa-B Inhibitor EpsilonNf-Kappa-BieI-Kappa-B-EpsilonIkb-EIkb-EpsilonIkappabepsilon |
| Database Links | Reactome: R-HSA-1169091 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Nf-Kappa-B Inhibitor Epsilon antibodyAnti-Nf-Kappa-Bie antibodyAnti-I-Kappa-B-Epsilon antibodyAnti-Ikb-E antibodyAnti-Ikb-Epsilon antibodyAnti-Ikappabepsilon antibodyAnti-NFKBIE antibodyAnti-IKBE antibody |
Information sourced from Uniprot.org