| Host: |
Rabbit |
| Applications: |
ELISA/IP/WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IKAP (1280-1330) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Purification: |
Affinity Purified |
| Concentration: |
0.5 µg/µl |
| Dilution Range: |
WB: 1:500ELISA: 1:50, 000IP: 1:200 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Elp1 |
| Gene ID: |
230233 |
| Uniprot ID: |
ELP1_MOUSE |
| Immunogen Region: |
1280-1330 |
| Immunogen: |
Synthetic peptide taken within amino acid region 1280-1330 on mouse Elongator Complex Protein 1. |
| Tissue Specificity | In the testis, expression is restricted to germ cells during spermatogenesis with no expression detected in somatic cells such as Sertoli cells or Leydig cells (at protein level). In the ovary, expressed in oocytes of primary, secondary and antral follicles (at protein level). Widely expressed in adult tissues with highest levels in brain and also expressed at all embryonic stages. |
| Post Translational Modifications | Phosphorylated. |
| Function | Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA. May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK). |
| Protein Name | Elongator Complex Protein 1Elp1Ikappab Kinase Complex-Associated ProteinIkk Complex-Associated Protein |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Elongator Complex Protein 1 antibodyAnti-Elp1 antibodyAnti-Ikappab Kinase Complex-Associated Protein antibodyAnti-Ikk Complex-Associated Protein antibodyAnti-Elp1 antibodyAnti-Ikap antibodyAnti-Ikbkap antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
