Anti-IgM antibody [8H6] (STJ16101752)

Anti-IgM antibody [8H6] (STJ16101752)

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STJ16101752-1
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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal anti-Immunoglobulin M for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : 8H6
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: Tissue culture supernatant with Sodium azide
Concentration: >=41 mg/L
Dilution Range: IHC-P 1:800
Storage Instruction: Store at 2-8°C for up to 1-year, upon receipt.
Gene Symbol: NAUniprot ID=IGM_HUMAN"
Immunogen: Prokaryotic recombinant protein corresponding to a portion of the N terminus of the heavy chain constant region.
Function Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen. IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B cell receptor, the secreted form is secreted in large amounts (, PubMed:16895553).
Protein Name Immunoglobulin Mu Heavy Chain
Immunoglobulin Mu Heavy Chain Ou
Cellular Localisation Secreted
Cell Membrane
Alternative Antibody Names Anti-Immunoglobulin Mu Heavy Chain antibody
Anti-Immunoglobulin Mu Heavy Chain Ou antibody

Information sourced from Uniprot.org

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