Anti-IGF2 antibody [4F1-6D6-2D10] (STJA0033492)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2b
ImmunogenSynthesized peptide derived from human IGF-2
General Information
| Short Description | Mouse monoclonal anti-IGF2 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 4F1-6D6-2D10 |
| Isotype | IgG2b |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Dilution Range | IHC 1:100-1:500 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | IGF2 |
| Gene ID | 3481 |
| Uniprot ID | IGF2_HUMAN |
| Immunogen | Synthesized peptide derived from human IGF-2 |
Additional Info
| Tissue Specificity | Expressed in heart, placenta, lung, liver, muscle, kidney, tongue, limb, eye and pancreas. |
| Post Translational Modifications | O-glycosylated with core 1 or possibly core 8 glycans. Thr-96 is a minor glycosylation site compared to Thr-99. Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2. |
| Function | The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate. Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. |
| Protein Name | Insulin-Like Growth Factor 2Insulin-Like Growth Factor IiIgf-IiSomatomedin-AT3m-11-Derived Growth Factor Cleaved Into - Insulin-Like Growth Factor Ii Ala-25 Del - Preptin |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-2404192Reactome: R-HSA-2428928Reactome: R-HSA-2428933Reactome: R-HSA-381426 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Insulin-Like Growth Factor 2 antibodyAnti-Insulin-Like Growth Factor Ii antibodyAnti-Igf-Ii antibodyAnti-Somatomedin-A antibodyAnti-T3m-11-Derived Growth Factor Cleaved Into - Insulin-Like Growth Factor Ii Ala-25 Del - Preptin antibodyAnti-IGF2 antibodyAnti-IGF-2 antibodyAnti-PP1446 antibody |
Information sourced from Uniprot.org