Anti-IFNL3 antibody (22-196) (STJ114774)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal IFNL3 (22-196) antibody for use in IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IFNL3 |
| Gene ID | 282617 |
| Uniprot ID | IFNL3_HUMAN |
| Immunogen Region | 22-196 |
| Immunogen Sequence | VPVARLRGALPDARGCHIAQ FKSLSPQELQAFKRAKDALE ESLLLKDCKCRSRLFPRTWD LRQLQVRERPVALEAELALT LKVLEATADTDPALGDVLDQ PLHTLHHILSQLRACIQPQP TAGPRTRGRLHHWLHRLQEA PKKESPGCLEASVTFNLFRL LTRDLNCVASGDLCV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 22-196 of human IFNL3 (NP_742151.2). |
Additional Info
| Function | Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. |
| Protein Name | Interferon Lambda-3Ifn-Lambda-3Cytokine Zcyto22Interleukin-28bIl-28bInterleukin-28cIl-28c |
| Database Links | Reactome: R-HSA-8854691 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interferon Lambda-3 antibodyAnti-Ifn-Lambda-3 antibodyAnti-Cytokine Zcyto22 antibodyAnti-Interleukin-28b antibodyAnti-Il-28b antibodyAnti-Interleukin-28c antibodyAnti-Il-28c antibodyAnti-IFNL3 antibodyAnti-IL28B antibodyAnti-IL28C antibodyAnti-ZCYTO22 antibody |
Information sourced from Uniprot.org