| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
IFNL2 |
| Gene ID: |
282616 |
| Uniprot ID: |
IFNL2_HUMAN |
| Immunogen Region: |
26-200 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 26-200 of human IFNL2 (NP_742150.1). |
| Immunogen Sequence: |
VPVARLHGALPDARGCHIAQ FKSLSPQELQAFKRAKDALE ESLLLKDCRCHSRLFPRTWD LRQLQVRERPMALEAELALT LKVLEATADTDPALVDVLDQ PLHTLHHILSQFRACIQPQP TAGPRTRGRLHHWLYRLQEA PKKESPGCLEASVTFNLFRL LTRDLNCVASGDLCV |
| Function | Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. |
| Protein Name | Interferon Lambda-2Ifn-Lambda-2Cytokine Zcyto20Interleukin-28aIl-28a |
| Database Links | Reactome: R-HSA-8854691 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interferon Lambda-2 antibodyAnti-Ifn-Lambda-2 antibodyAnti-Cytokine Zcyto20 antibodyAnti-Interleukin-28a antibodyAnti-Il-28a antibodyAnti-IFNL2 antibodyAnti-IL28A antibodyAnti-ZCYTO20 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
