Anti-IFI6 antibody (80-130) {Biotin} (STJ505936)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationBiotin
IsotypeIgG
ImmunogenSynthetic peptide take within amino acid region 80-130 on human Interferon alpha-inducible protein 6.
General Information
| Short Description | Rabbit polyclonal antibody anti-IFI6 (80-130) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IP/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Biotin |
| Concentration | 0.5-1.5 µg/µl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500-1:5, 000ELISA: 1:50, 000IP: 1:200 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | IFI6 |
| Gene ID | 2537 |
| Uniprot ID | IFI6_HUMAN |
| Immunogen | Synthetic peptide take within amino acid region 80-130 on human Interferon alpha-inducible protein 6. |
| Immunogen Region | 80-130 |
Additional Info
| Function | Interferon-stimulated protein that plays an important role in innate immune response against a wide variety of viruses. Inhibits flavivirus replication by preventing the formation of virus-induced endoplasmic reticulum membrane invaginations, which are double-membrane vesicles that flaviviruses use for their replication. Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, whose activation is required for entry of the virus into cells. Within the nucleus, restricts hepatitis B virus/HBV promoter activity leading to substantial reduction of viral replication and gene expression. Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis. However, it has also been shown to have a pro-apoptotic activity. Modulates innate immune response mediated by RIGI by preventing its activation. |
| Protein Name | Interferon Alpha-Inducible Protein 6Interferon-Induced Protein 6-16Ifi-6-16 |
| Database Links | Reactome: R-HSA-909733 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinMitochondrion Inner Membrane |
| Alternative Antibody Names | Anti-Interferon Alpha-Inducible Protein 6 antibodyAnti-Interferon-Induced Protein 6-16 antibodyAnti-Ifi-6-16 antibodyAnti-IFI6 antibodyAnti-G1P3 antibody |
Information sourced from Uniprot.org