| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Immediate early response gene 5 protein (28-78 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IER5 |
| Gene ID: |
51278 |
| Uniprot ID: |
IER5_HUMAN |
| Immunogen Region: |
28-78 aa |
| Specificity: |
This antibody detects endogenous levels of IER5 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human IER5 at the amino acid range 28-78 |
| Function | Plays a role as a transcription factor. Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1-dependent manner. Mediates negative transcriptional regulation of CDC25B expression. Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A. Involved in the regulation of cell proliferation and resistance to thermal stress. Involved in the cell cycle checkpoint and survival in response to ionizing radiation. Associates with chromatin to the CDC25B promoter. |
| Protein Name | Immediate Early Response Gene 5 Protein |
| Cellular Localisation | NucleusCytoplasmPredominantly CytoplasmicTranslocated In The Nucleus During Heat Shock |
| Alternative Antibody Names | Anti-Immediate Early Response Gene 5 Protein antibodyAnti-IER5 antibodyAnti-PP4583 antibodyAnti-SBBI48 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
