| Short Description : | Rabbit polyclonal anti-Immediate early response gene 5 protein (28-78 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IER5 |
| Gene ID: | 51278 |
| Uniprot ID: | IER5_HUMAN |
| Immunogen: | Synthesized peptide derived from the human IER5 at the amino acid range 28-78 |
| Immunogen Region: | 28-78 aa |
| Specificity: | This antibody detects endogenous levels of IER5 at Human/Mouse |
| Function | Plays a role as a transcription factor. Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1-dependent manner. Mediates negative transcriptional regulation of CDC25B expression. Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A. Involved in the regulation of cell proliferation and resistance to thermal stress. Involved in the cell cycle checkpoint and survival in response to ionizing radiation. Associates with chromatin to the CDC25B promoter. |
| Protein Name | Immediate Early Response Gene 5 Protein |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmPredominantly CytoplasmicTranslocated In The Nucleus During Heat Shock |
| Alternative Antibody Names | Anti-Immediate Early Response Gene 5 Protein antibodyAnti-IER5 antibodyAnti-PP4583 antibodyAnti-SBBI48 antibody |
Information sourced from Uniprot.org
