| Host: | Rabbit |
| Applications: | ELISA/IP/WB |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-IDO1 (100-150) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.5-1.5 µg/µl |
| Dilution Range: | WB: 1:2, 500-1:5, 000 ELISA: 1:50, 000 IP: 1:200 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | IDO1 |
| Gene ID: | 3620 |
| Uniprot ID: | I23O1_HUMAN |
| Immunogen Region: | 100-150 |
| Immunogen: | Synthetic peptide taken within amino acid region 100-150 on human Indoleamine 2, 3-dioxygenase 1 protein. |
| Function | Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity. Limits the growth of intracellular pathogens by depriving tryptophan. Protects the fetus from maternal immune rejection. |
| Protein Name | Indoleamine 2 -3-Dioxygenase 1 Ido-1 Indoleamine-Pyrrole 2 -3-Dioxygenase |
| Database Links | Reactome: R-HSA-71240 |
| Cellular Localisation | Cytoplasm Cytosol |
| Alternative Antibody Names | Anti-Indoleamine 2 -3-Dioxygenase 1 antibody Anti-Ido-1 antibody Anti-Indoleamine-Pyrrole 2 -3-Dioxygenase antibody Anti-IDO1 antibody Anti-IDO antibody Anti-INDO antibody |
Information sourced from Uniprot.org