Anti-IDO1 antibody (100-150) {Biotin} (STJ501390)

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STJ501390-100
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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-IDO1 (100-150) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Biotin
Isotype: IgG
Formulation: Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide).
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:2, 500-1:5, 000
ELISA: 1:50, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: IDO1
Gene ID: 3620
Uniprot ID: I23O1_HUMAN
Immunogen Region: 100-150
Immunogen: Synthetic peptide taken within amino acid region 100-150 on human Indoleamine 2, 3-dioxygenase 1 protein.
Function Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity. Limits the growth of intracellular pathogens by depriving tryptophan. Protects the fetus from maternal immune rejection.
Protein Name Indoleamine 2 -3-Dioxygenase 1
Ido-1
Indoleamine-Pyrrole 2 -3-Dioxygenase
Database Links Reactome: R-HSA-71240
Cellular Localisation Cytoplasm
Cytosol
Alternative Antibody Names Anti-Indoleamine 2 -3-Dioxygenase 1 antibody
Anti-Ido-1 antibody
Anti-Indoleamine-Pyrrole 2 -3-Dioxygenase antibody
Anti-IDO1 antibody
Anti-IDO antibody
Anti-INDO antibody

Information sourced from Uniprot.org

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