| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IDH3A |
| Gene ID: | 3419 |
| Uniprot ID: | IDH3A_HUMAN |
| Immunogen Region: | 28-366 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-366 of human IDH3A (NP_005521.1). |
| Immunogen Sequence: | TGGVQTVTLIPGDGIGPEIS AAVMKIFDAAKAPIQWEERN VTAIQGPGGKWMIPSEAKES MDKNKMGLKGPLKTPIAAGH PSMNLLLRKTFDLYANVRPC VSIEGYKTPYTDVNIVTIRE NTEGEYSGIEHVIVDGVVQS IKLITEGASKRIAEFAFEYA RNNHRSNVTAVHKANIMRMS DGLFLQKCREVAESCKDIKF NEMYLDTVCLNMVQDPSQFD VLVMPNLYGDILSDLCAGL |
| Function | Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. |
| Protein Name | Isocitrate Dehydrogenase Nad Subunit Alpha - MitochondrialIsocitric Dehydrogenase Subunit AlphaNad(+-Specific Icdh Subunit Alpha |
| Database Links | Reactome: R-HSA-71403Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Isocitrate Dehydrogenase Nad Subunit Alpha - Mitochondrial antibodyAnti-Isocitric Dehydrogenase Subunit Alpha antibodyAnti-Nad(+-Specific Icdh Subunit Alpha antibodyAnti-IDH3A antibody |
Information sourced from Uniprot.org