| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/IP/ELISA/ChIP |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:20-1:50IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specifi |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IDH2 |
| Gene ID: | 3418 |
| Uniprot ID: | IDHP_HUMAN |
| Immunogen Region: | 193-452 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 193-452 of human IDH2 (NP_002159.2). |
| Immunogen Sequence: | KMVFTPKDGSGVKEWEVYNF PAGGVGMGMYNTDESISGFA HSCFQYAIQKKWPLYMSTKN TILKAYDGRFKDIFQEIFDK HYKTDFDKNKIWYEHRLIDD MVAQVLKSSGGFVWACKNYD GDVQSDILAQGFGSLGLMTS VLVCPDGKTIEAEAAHGTVT RHYREHQKGRPTSTNPIASI FAWTRGLEHRGKLDGNQDLI RFAQMLEKVCVETVESGAMT KDLAGCIHGLSNVKLNEHF |
| Post Translational Modifications | Acetylation at Lys-413 dramatically reduces catalytic activity. Deacetylated by SIRT3. |
| Function | Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex. |
| Protein Name | Isocitrate Dehydrogenase Nadp - MitochondrialIdhIcd-MIdpNadp(+-Specific IcdhOxalosuccinate Decarboxylase |
| Database Links | Reactome: R-HSA-2151201Reactome: R-HSA-71403Reactome: R-HSA-9837999Reactome: R-HSA-9854311 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Isocitrate Dehydrogenase Nadp - Mitochondrial antibodyAnti-Idh antibodyAnti-Icd-M antibodyAnti-Idp antibodyAnti-Nadp(+-Specific Icdh antibodyAnti-Oxalosuccinate Decarboxylase antibodyAnti-IDH2 antibody |
Information sourced from Uniprot.org