Host: | Rabbit |
Applications: | WB/IF/ELISA |
Reactivity: | Human/Rat/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-Intercellular adhesion molecule 3 (484-533 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:5000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | ICAM3 |
Gene ID: | 3385 |
Uniprot ID: | ICAM3_HUMAN |
Immunogen Region: | 484-533 aa |
Specificity: | CD50 Polyclonal Antibody detects endogenous levels of CD50 protein. |
Immunogen: | The antiserum was produced against synthesized peptide derived from the human CD50/ICAM-3 at the amino acid range 484-533 |
Post Translational Modifications | Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues. N-glycosylated.glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains. |
Function | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages. |
Protein Name | Intercellular Adhesion Molecule 3Icam-3Cdw50Icam-RCd Antigen Cd50 |
Database Links | Reactome: R-HSA-198933Reactome: R-HSA-216083Reactome: R-HSA-5621575 |
Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
Alternative Antibody Names | Anti-Intercellular Adhesion Molecule 3 antibodyAnti-Icam-3 antibodyAnti-Cdw50 antibodyAnti-Icam-R antibodyAnti-Cd Antigen Cd50 antibodyAnti-ICAM3 antibody |
Information sourced from Uniprot.org