| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ICAM3 |
| Gene ID: | 3385 |
| Uniprot ID: | ICAM3_HUMAN |
| Immunogen Region: | 270-490 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 270-490 of human ICAM3 (NP_002153.2). |
| Immunogen Sequence: | HGDTLTATATATARADQEGA REIVCNVTLGGERREARENL TVFSFLGPIVNLSEPTAHEG STVTVSCMAGARVQVTLDGV PAAAPGQPAQLQLNATESDD GRSFFCSATLEVDGEFLHRN SSVQLRVLYGPKIDRATCPQ HLKWKDKTRHVLQCQARGNP YPELRCLKEGSSREVPVGIP FFVNVTHNGTYQCQASSSRG KYTLVVVMDIEAGSSHFVPV F |
| Tissue Specificity | Leukocytes. |
| Post Translational Modifications | Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues. N-glycosylated.glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains. |
| Function | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages. |
| Protein Name | Intercellular Adhesion Molecule 3Icam-3Cdw50Icam-RCd Antigen Cd50 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-216083Reactome: R-HSA-5621575 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Intercellular Adhesion Molecule 3 antibodyAnti-Icam-3 antibodyAnti-Cdw50 antibodyAnti-Icam-R antibodyAnti-Cd Antigen Cd50 antibodyAnti-ICAM3 antibody |
Information sourced from Uniprot.org