Anti-IBP/DEF6 antibody (N-Term) (STJ70543)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-IBP/DEF6 (N-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Pig/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:2000.WB: Approx. 70kDa band observed in Human Thymus lysates (calculated MW of 73.9kDa according to NP_071330.3). Recommended concentration: 1-3µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | DEF6 |
| Gene ID | 50619 |
| Uniprot ID | DEFI6_HUMAN |
| Accession Number | NP_071330.3 |
| Immunogen Region | N-Term |
| Immunogen Sequence | ALRKELLKSIWYA |
Additional Info
| Post Translational Modifications | Tyrosine-phosphorylated by tyrosine-protein kinase LCK in response to T-cell activation. |
| Function | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling. |
| Protein Name | Differentially Expressed In Fdcp 6 HomologDef-6Irf4-Binding Protein |
| Database Links | Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404 |
| Cellular Localisation | CytoplasmCell MembraneNucleusCytoskeletonPerinuclear RegionCell ProjectionFilopodiumRecruited To The Plasma Membrane Upon Binding Phosphatidylinositol 345-TrisphosphateBinds To Actin Filaments |
| Alternative Antibody Names | Anti-Differentially Expressed In Fdcp 6 Homolog antibodyAnti-Def-6 antibodyAnti-Irf4-Binding Protein antibodyAnti-DEF6 antibodyAnti-IBP antibody |
Information sourced from Uniprot.org