Anti-HYOU1 antibody (1-150) [S0MR] (STJ11101270)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal ORP150 (1-150) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S0MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HYOU1 |
| Gene ID | 10525 |
| Uniprot ID | HYOU1_HUMAN |
| Immunogen Region | 1-150 |
| Immunogen Sequence | MADKVRRQRPRRRVCWALVA VLLADLLALSDTLAVMSVDL GSESMKVAIVKPGVPMEIVL NKESRRKTPVIVTLKENERF FGDSAASMAIKNPKATLRYF QHLLGKQADNPHVALYQARF PEHELTFDPQRQTVHFQISS QLQFSPEEVL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human ORP150/GRP170/HSP12A (Q9Y4L1). |
Additional Info
| Tissue Specificity | Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers. |
| Function | Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress. May play a role as a molecular chaperone and participate in protein folding. |
| Protein Name | Hypoxia Up-Regulated Protein 1150 Kda Oxygen-Regulated ProteinOrp-150170 Kda Glucose-Regulated ProteinGrp-170Heat Shock Protein Family H Member 4 |
| Database Links | Reactome: R-HSA-3000484Reactome: R-HSA-381038 |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Hypoxia Up-Regulated Protein 1 antibodyAnti-150 Kda Oxygen-Regulated Protein antibodyAnti-Orp-150 antibodyAnti-170 Kda Glucose-Regulated Protein antibodyAnti-Grp-170 antibodyAnti-Heat Shock Protein Family H Member 4 antibodyAnti-HYOU1 antibodyAnti-GRP170 antibodyAnti-HSPH4 antibodyAnti-ORP150 antibody |
Information sourced from Uniprot.org