| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S5225RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HYAL1 |
| Gene ID: | 3373 |
| Uniprot ID: | HYAL1_HUMAN |
| Immunogen Region: | 22-435 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-435 of human HYAL1 (NP_149349.2). |
| Immunogen Sequence: | FRGPLLPNRPFTTVWNANTQ WCLERHGVDVDVSVFDVVAN PGQTFRGPDMTIFYSSQLGT YPYYTPTGEPVFGGLPQNAS LIAHLARTFQDILAAIPAPD FSGLAVIDWEAWRPRWAFNW DTKDIYRQRSRALVQAQHPD WPAPQVEAVAQDQFQGAARA WMAGTLQLGRALRPRGLWGF YGFPDCYNYDFLSPNYTGQC PSGIRAQNDQLGWLWGQSRA LYPSIYMPAVLEGTGKSQM |
| Tissue Specificity | Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues. |
| Function | May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. |
| Protein Name | Hyaluronidase-1Hyal-1Hyaluronoglucosaminidase-1Lung Carcinoma Protein 1Luca-1 |
| Database Links | Reactome: R-HSA-2024101Reactome: R-HSA-2160916Reactome: R-HSA-2206280 |
| Cellular Localisation | SecretedLysosome |
| Alternative Antibody Names | Anti-Hyaluronidase-1 antibodyAnti-Hyal-1 antibodyAnti-Hyaluronoglucosaminidase-1 antibodyAnti-Lung Carcinoma Protein 1 antibodyAnti-Luca-1 antibodyAnti-HYAL1 antibodyAnti-LUCA1 antibody |
Information sourced from Uniprot.org