![Anti-HTT nanobody [SAA1178] (STJN000223)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200836/413018/STJN000223-SDS-PAGE-1__52342.1749232535.jpg?c=1 "Anti-HTT nanobody [SAA1178] (STJN000223)")
![Anti-HTT nanobody [SAA1178] (STJN000223)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200836/413018/STJN000223-SDS-PAGE-1__52342.1749232535.jpg?c=1 "Anti-HTT nanobody [SAA1178] (STJN000223)")
Anti-HTT nanobody [SAA1178] (STJN000223)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Huntingtin is suitable for use in Dot Blot, ELISA and SPR research applications. |
| Applications | DB/ELISA/SPR |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1178 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | HTT |
| Gene ID | 3064 |
| Uniprot ID | HD_HUMAN |
Additional Info
| Post Translational Modifications | Huntingtin: Cleaved by caspases downstream of the polyglutamine stretch. The resulting N-terminal fragments are cytotoxic and provokes apoptosis. Huntingtin: Forms with expanded polyglutamine expansion are specifically ubiquitinated by SYVN1, which promotes their proteasomal degradation. Huntingtin: Phosphorylation at Ser-1179 and Ser-1199 by CDK5 in response to DNA damage in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Huntingtin, myristoylated N-terminal fragment: Myristoylated at Gly-551, following proteolytic cleavage at Asp-550. |
| Function | Huntingtin: May play a role in microtubule-mediated transport or vesicle function. Huntingtin, myristoylated N-terminal fragment: Promotes the formation of autophagic vesicles. |
| Protein Name | HuntingtinHuntington Disease ProteinHd Protein Cleaved Into - Huntingtin - Myristoylated N-Terminal Fragment |
| Database Links | Reactome: R-HSA-9022692 |
| Cellular Localisation | Huntingtin: CytoplasmNucleusEarly EndosomeThe Mutant Huntingtin Protein Colocalizes With Akap8l In The Nuclear Matrix Of Huntington Disease NeuronsShuttles Between Cytoplasm And Nucleus In A Ran Gtpase-Independent MannerRecruits Onto Early Endosomes In A Rab5- And Hap40-Dependent FashionHuntingtinMyristoylated N-Terminal Fragment: Cytoplasmic VesicleAutophagosome |
| Alternative Nanobody Names | Anti-Huntingtin nanobodyAnti-Huntington Disease Protein nanobodyAnti-Hd Protein Cleaved Into - Huntingtin - Myristoylated N-Terminal Fragment nanobodyAnti-HTT nanobodyAnti-HD nanobodyAnti-IT15 nanobody |
Information sourced from Uniprot.org