| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-5-hydroxytryptamine receptor 4 (21-70 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:5000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HTR4 |
| Gene ID: | 3360 |
| Uniprot ID: | 5HT4R_HUMAN |
| Immunogen Region: | 21-70 aa |
| Specificity: | SR-4 Polyclonal Antibody detects endogenous levels of SR-4 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human 5-HT-4 at the amino acid range 21-70 |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. |
| Protein Name | 5-Hydroxytryptamine Receptor 45-Ht-45-Ht4Serotonin Receptor 4 |
| Database Links | Reactome: R-HSA-390666Reactome: R-HSA-418555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndosome MembraneInteraction With Snx27 Mediates Recruitment To Early EndosomesWhile Interaction With Nherf1 And Ezr Might Target The Protein To Specialized Subcellular RegionsSuch As Microvilli |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 4 antibodyAnti-5-Ht-4 antibodyAnti-5-Ht4 antibodyAnti-Serotonin Receptor 4 antibodyAnti-HTR4 antibody |
Information sourced from Uniprot.org