| Host: | Rabbit |
| Applications: | ELISA/IHC/IP/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-HTR2A (400-450) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.5 µg/µl |
| Dilution Range: | WB: 1:500 ELISA: 1:50, 000 IP: 1:200 IHC: 1:50-1:100 ICC: 1:50-1:100 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | HTR2A |
| Gene ID: | 3356 |
| Uniprot ID: | 5HT2A_HUMAN |
| Immunogen Region: | 400-450 |
| Immunogen: | Synthetic peptide taken within amino acid region 400-450 on human 5-hydroxytryptamine receptor 2A. |
| Tissue Specificity | Detected in brain cortex (at protein level). Detected in blood platelets. |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR2A is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction. (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV. |
| Protein Name | 5-Hydroxytryptamine Receptor 2a 5-Ht-2 5-Ht-2a Serotonin Receptor 2a |
| Database Links | Reactome: R-HSA-390666 Reactome: R-HSA-416476 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Cell Projection Dendrite Axon Cytoplasmic Vesicle Membrane Caveola Presynapse |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 2a antibody Anti-5-Ht-2 antibody Anti-5-Ht-2a antibody Anti-Serotonin Receptor 2a antibody Anti-HTR2A antibody Anti-HTR2 antibody |
Information sourced from Uniprot.org