Anti-HTR1D antibody (150-250) (STJ28077)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal HTR1D (150-250) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HTR1D |
| Gene ID | 3352 |
| Uniprot ID | 5HT1D_HUMAN |
| Immunogen Region | 150-250 |
| Immunogen Sequence | RTAGHAATMIAIVWAISICI SIPPLFWRQAKAQEEMSDCL VNTSQISYTIYSTCGAFYIP SVLLIILYGRIYRAARNRIL NPPSLYGKRFTTAHLITGSA G |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human HTR1D (NP_000855.1). |
Additional Info
| Tissue Specificity | Detected in brain neocortex and caudate nucleus (at protein level). |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction. |
| Protein Name | 5-Hydroxytryptamine Receptor 1d5-Ht-1d5-Ht1dSerotonin 1d Alpha Receptor5-Ht-1d-AlphaSerotonin Receptor 1d |
| Database Links | Reactome: R-HSA-390666Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 1d antibodyAnti-5-Ht-1d antibodyAnti-5-Ht1d antibodyAnti-Serotonin 1d Alpha Receptor antibodyAnti-5-Ht-1d-Alpha antibodyAnti-Serotonin Receptor 1d antibodyAnti-HTR1D antibodyAnti-HTR1DA antibodyAnti-HTRL antibody |
Information sourced from Uniprot.org