| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Heat shock protein 105 kDa (791-840 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HSPH1 |
| Gene ID: | 10808 |
| Uniprot ID: | HS105_HUMAN |
| Immunogen Region: | 791-840 aa |
| Specificity: | HSP105 Polyclonal Antibody detects endogenous levels of HSP105 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human HSP105 at the amino acid range 791-840 |
| Post Translational Modifications | Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity. |
| Function | Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. |
| Protein Name | Heat Shock Protein 105 KdaAntigen Ny-Co-25Heat Shock 110 Kda ProteinHeat Shock Protein Family H Member 1 |
| Database Links | Reactome: R-HSA-3000484Reactome: R-HSA-3371453 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Heat Shock Protein 105 Kda antibodyAnti-Antigen Ny-Co-25 antibodyAnti-Heat Shock 110 Kda Protein antibodyAnti-Heat Shock Protein Family H Member 1 antibodyAnti-HSPH1 antibodyAnti-HSP105 antibodyAnti-HSP110 antibodyAnti-KIAA0201 antibody |
Information sourced from Uniprot.org