Host: | Rabbit |
Applications: | WB/IHC/IF/ELISA |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-Heat shock protein 105 kDa (791-840 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:10000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | HSPH1 |
Gene ID: | 10808 |
Uniprot ID: | HS105_HUMAN |
Immunogen Region: | 791-840 aa |
Specificity: | HSP105 Polyclonal Antibody detects endogenous levels of HSP105 protein. |
Immunogen: | The antiserum was produced against synthesized peptide derived from the human HSP105 at the amino acid range 791-840 |
Post Translational Modifications | Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity. |
Function | Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. |
Protein Name | Heat Shock Protein 105 Kda Antigen Ny-Co-25 Heat Shock 110 Kda Protein Heat Shock Protein Family H Member 1 |
Database Links | Reactome: R-HSA-3000484 Reactome: R-HSA-3371453 |
Cellular Localisation | Cytoplasm |
Alternative Antibody Names | Anti-Heat Shock Protein 105 Kda antibody Anti-Antigen Ny-Co-25 antibody Anti-Heat Shock 110 Kda Protein antibody Anti-Heat Shock Protein Family H Member 1 antibody Anti-HSPH1 antibody Anti-HSP105 antibody Anti-HSP110 antibody Anti-KIAA0201 antibody |
Information sourced from Uniprot.org