| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | HSPBP1 |
| Gene ID: | 23640 |
| Uniprot ID: | HPBP1_HUMAN |
| Immunogen Region: | 1-359 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-359 of human HSPBP1 (NP_036399.3). |
| Immunogen Sequence: | MSDEGSRGSRLPLALPPASQ GCSSGGGGGGSSAGGSGNSR PPRNLQGLLQMAITAGSEEP DPPPEPMSEERRQWLQEAMS AAFRGQREEVEQMKSCLRVL SQPMPPTAGEAEQAADQQER EGALELLADLCENMDNAADF CQLSGMHLLVGRYLEAGAAG LRWRAAQLIGTCSQNVAAIQ EQVLGLGALRKLLRLLDRDA CDTVRVKALFAISCLVREQE AGLLQFLRLDGFSVLMRAM |
| Tissue Specificity | Ubiquitous. |
| Function | Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR. |
| Protein Name | Hsp70-Binding Protein 1Hspbp1Heat Shock Protein-Binding Protein 1Hsp70-Binding Protein 2Hspbp2Hsp70-Interacting Protein 1Hsp70-Interacting Protein 2 |
| Alternative Antibody Names | Anti-Hsp70-Binding Protein 1 antibodyAnti-Hspbp1 antibodyAnti-Heat Shock Protein-Binding Protein 1 antibodyAnti-Hsp70-Binding Protein 2 antibodyAnti-Hspbp2 antibodyAnti-Hsp70-Interacting Protein 1 antibodyAnti-Hsp70-Interacting Protein 2 antibodyAnti-HSPBP1 antibodyAnti-HSPBP antibodyAnti-PP1845 antibody |
Information sourced from Uniprot.org