Anti-HSPB11 antibody (1-144) (STJ11100181)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal HSPB11 (1-144) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IFT25 |
| Gene ID | 51668 |
| Uniprot ID | IFT25_HUMAN |
| Immunogen Region | 1-144 |
| Immunogen Sequence | MRKIDLCLSSEGSEVILATS SDEKHPPENIIDGNPETFWT TTGMFPQEFIICFHKHVRIE RLVIQSYFVQTLKIEKSTSK EPVDFEQWIEKDLVHTEGQL QNEEIVAHDGSATYLRFIIV SAFDHFASVHSVSAEGTVVS NLSS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-144 of human HSPB11 (NP_057210.2). |
Additional Info
| Tissue Specificity | Detected in placenta. |
| Function | Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation. |
| Protein Name | Intraflagellar Transport Protein 25 HomologHeat Shock Protein Beta-11Hspb11Heat Shock Protein Family B Member 11Placental Protein 25Pp25 |
| Database Links | Reactome: R-HSA-5620924 |
| Cellular Localisation | Cell ProjectionCilium |
| Alternative Antibody Names | Anti-Intraflagellar Transport Protein 25 Homolog antibodyAnti-Heat Shock Protein Beta-11 antibodyAnti-Hspb11 antibodyAnti-Heat Shock Protein Family B Member 11 antibodyAnti-Placental Protein 25 antibodyAnti-Pp25 antibodyAnti-IFT25 antibodyAnti-C1orf41 antibodyAnti-HSPB11 antibodyAnti-HSPC034 antibody |
Information sourced from Uniprot.org