| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HSPA2 (400-639) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HSPA2 |
| Gene ID: |
3306 |
| Uniprot ID: |
HSP72_HUMAN |
| Immunogen Region: |
400-639 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 400-639 of human HSPA2 (NP_068814.2). |
| Immunogen Sequence: |
TPLSLGIETAGGVMTPLIKR NTTIPTKQTQTFTTYSDNQS SVLVQVYEGERAMTKDNNLL GKFDLTGIPPAPRGVPQIEV TFDIDANGILNVTAADKSTG KENKITITNDKGRLSKDDID RMVQEAERYKSEDEANRDRV AAKNALESYTYNIKQTVEDE KLRGKISEQDKNKILDKCQE VINWLDRNQMAEKDEYEHKQ KELERVCNPIISKLYQGGPG GGSGGGGSGASGGPTIEEV |
| Function | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells. |
| Protein Name | Heat Shock-Related 70 Kda Protein 2Heat Shock 70 Kda Protein 2 |
| Database Links | Reactome: R-HSA-1221632Reactome: R-HSA-3371453Reactome: R-HSA-3371497Reactome: R-HSA-3371568 |
| Cellular Localisation | CytoplasmCytoskeletonSpindleColocalizes With Shcbp1l At Spindle During The Meiosis Process |
| Alternative Antibody Names | Anti-Heat Shock-Related 70 Kda Protein 2 antibodyAnti-Heat Shock 70 Kda Protein 2 antibodyAnti-HSPA2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
