• Western blot analysis of lysates from MCF-7 cells and HUVEC cells, using HS71L Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of MCF-7 cells using HSP70 Polyclonal Antibody diluted at 1：1000
  • Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100 (4°C overnight). High-pressure and temperature Tris-EDTA, pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.
  • Western blot analysis of various cells using HSP70 Polyclonal Antibody diluted at 1：1000

Anti-HSP70L antibody (221-270 aa) (STJ93607)

SKU:
STJ93607

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Heat shock 70 kDa protein 1-like and OBSOLETE (221-270 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: HSPA1L
Gene ID: 3305
Uniprot ID: HS71L_HUMAN
Immunogen Region: 221-270 aa
Specificity: HSP70 Polyclonal Antibody detects endogenous levels of HSP70 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human HSPA1L at the amino acid range 221-270
Function Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Positive regulator of PRKN translocation to damaged mitochondria.
Protein Name Heat Shock 70 Kda Protein 1-Like
Heat Shock 70 Kda Protein 1l
Heat Shock 70 Kda Protein 1-Hom
Hsp70-Hom
Database Links Reactome: R-HSA-3371453
Reactome: R-HSA-3371497
Reactome: R-HSA-3371568
Reactome: R-HSA-3371571
Alternative Antibody Names Anti-Heat Shock 70 Kda Protein 1-Like antibody
Anti-Heat Shock 70 Kda Protein 1l antibody
Anti-Heat Shock 70 Kda Protein 1-Hom antibody
Anti-Hsp70-Hom antibody
Anti-HSPA1L antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance