| Post Translational Modifications | Phosphorylated. |
| Function | Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis. Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2). Converts dihydrotestosterone (DHT) to its inactive form 5a-androstane-3b,17b-diol. Converts moderately progesterone to 3beta-hydroxypregn-4-ene-20-one, leading to its inactivation. Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase. Isoform 3: Does not have enzymatic activities toward E1 and DHT. |
| Protein Name | 3-Keto-Steroid Reductase/17-Beta-Hydroxysteroid Dehydrogenase 717-Beta-Hydroxysteroid Dehydrogenase 717-Beta-Hsd 73-Keto-Steroid ReductaseDihydrotestosterone OxidoreductaseEstradiol 17-Beta-Dehydrogenase 7Short Chain Dehydrogenase/Reductase Family 37c Member 1 |
| Database Links | Reactome: R-HSA-191273 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-3-Keto-Steroid Reductase/17-Beta-Hydroxysteroid Dehydrogenase 7 antibodyAnti-17-Beta-Hydroxysteroid Dehydrogenase 7 antibodyAnti-17-Beta-Hsd 7 antibodyAnti-3-Keto-Steroid Reductase antibodyAnti-Dihydrotestosterone Oxidoreductase antibodyAnti-Estradiol 17-Beta-Dehydrogenase 7 antibodyAnti-Short Chain Dehydrogenase/Reductase Family 37c Member 1 antibodyAnti-HSD17B7 antibodyAnti-17HSD7 antibodyAnti-SDR37C1 antibodyAnti-UNQ2563 antibodyAnti-PRO6243 antibody |
Information sourced from Uniprot.org
