Anti-HPS4 antibody (387-708) (STJ118597)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal HPS4 (387-708) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HPS4 |
| Gene ID | 89781 |
| Uniprot ID | HPS4_HUMAN |
| Immunogen Region | 387-708 |
| Immunogen Sequence | FAFLHVPVPDGRAPYCKASL SASSSLEPTPPEDTAISSLR PPSAPEMLTQHGAQEQLEDH PGHSSQAPIPRADPLPRRTR RPLLLPRLDPGQRGNKLPTG EQGLDEDVDGVCESHAAPGL ECSSGSANCQGAGPSADGIS SRLTPAESCMGLVRMNLYTH CVKGLVLSLLAEEPLLGDSA AIEEVYHSSLASLNGLEVHL KETLPRDEAASTSSTYNFTH YDRIQSLLMANLPQVATPQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 387-708 of human HPS4 (NP_071364.4). |
Additional Info
| Function | Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38. |
| Protein Name | Bloc-3 Complex Member Hps4Hermansky-Pudlak Syndrome 4 ProteinLight-Ear Protein Homolog |
| Database Links | Reactome: R-HSA-8876198 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Bloc-3 Complex Member Hps4 antibodyAnti-Hermansky-Pudlak Syndrome 4 Protein antibodyAnti-Light-Ear Protein Homolog antibodyAnti-HPS4 antibodyAnti-KIAA1667 antibody |
Information sourced from Uniprot.org