| Host: | Rabbit |
| Applications: | IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HPS1 |
| Gene ID: | 3257 |
| Uniprot ID: | HPS1_HUMAN |
| Immunogen Region: | 1-324 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-324 of human HPS1 (NP_872577.1). |
| Immunogen Sequence: | MKCVLVATEGAEVLFYWTDQ EFEESLRLKFGQSENEEEEL PALEDQLSTLLAPVIISSMT MLEKLSDTYTCFSTENGNFL YVLHLFGECLFIAINGDHTE SEGDLRRKLYVLKYLFEVHF GLVTVDGHLIRKELRPPDLA QRVQLWEHFQSLLWTYSRLR EQEQCFAVEALERLIHPQLC ELCIEALERHVIQAVNTSPE RGGEEALHAFLLVHSKLLAF YSSHSASSLRPADLLALIL |
| Tissue Specificity | Ubiquitous. |
| Function | Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38. |
| Protein Name | Bloc-3 Complex Member Hps1Hermansky-Pudlak Syndrome 1 Protein |
| Database Links | Reactome: R-HSA-8876198 |
| Alternative Antibody Names | Anti-Bloc-3 Complex Member Hps1 antibodyAnti-Hermansky-Pudlak Syndrome 1 Protein antibodyAnti-HPS1 antibodyAnti-HPS antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and TXNDC5 knockout (KO) 293T cells, using [KO Validated] TXNDC5 Rabbit polyclonal antibody (STJ11100807) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/89743/358218/STJ11100807_1__82919.1713122544.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and TXNDC5 knockout (KO) 293T cells, using [KO Validated] TXNDC5 Rabbit polyclonal antibody (STJ11100807) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")