Anti-HORMAD2 antibody (STJA0004598)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenFusion protein of human HORMAD2
General Information
| Short Description | Rabbit polyclonal anti-Horma Domain-Containing Protein 2 for use in IHC and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.96 mg/mL |
| Purification | Antigen affinity purification |
| Dilution Range | IHC 1:50-1:100 |
| Formulation | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | HORMAD2 |
| Gene ID | 150280 |
| Uniprot ID | HORM2_HUMAN |
| Immunogen | Fusion protein of human HORMAD2 |
Additional Info
| Tissue Specificity | Highly expressed in testis (at protein level). Expressed in lung adenocarcinoma and squamous cell carcinoma (at protein level). Expressed at lower levels in the liver, brain and kidney. |
| Post Translational Modifications | Phosphorylated in a SPO11-dependent manner. |
| Function | Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation. |
| Protein Name | Horma Domain-Containing Protein 2 |
| Database Links | |
| Cellular Localisation | NucleusChromosomePreferentially Localizes To Unsynapsed Or Desynapsed Chromosomal Regions During The Male And Female Prophase I Stage Of MeiosisTrip13 Is Required For Depletion From Synapsed Chromosomes |
| Alternative Antibody Names | Anti-Horma Domain-Containing Protein 2 antibodyAnti-HORMAD2 antibody |
Information sourced from Uniprot.org