| Tissue Specificity | Highly expressed in testis (at protein level). Expressed in lung adenocarcinoma and squamous cell carcinoma (at protein level). Expressed at lower levels in the liver, brain and kidney. |
| Post Translational Modifications | Phosphorylated in a SPO11-dependent manner. |
| Function | Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation. |
| Protein Name | Horma Domain-Containing Protein 2 |
| Cellular Localisation | NucleusChromosomePreferentially Localizes To Unsynapsed Or Desynapsed Chromosomal Regions During The Male And Female Prophase I Stage Of MeiosisTrip13 Is Required For Depletion From Synapsed Chromosomes |
| Alternative Antibody Names | Anti-Horma Domain-Containing Protein 2 antibodyAnti-HORMAD2 antibody |
Information sourced from Uniprot.org
