| Tissue Specificity | Expressed in the embryonic and adult heart and in the adult brain, liver, lung, skeletal muscle, intestine and spleen. Throughout embryonic and postnatal development, it is expressed in the myocardium. |
| Function | Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding. |
| Protein Name | Homeodomain-Only ProteinHomeobox-Only ProteinOdd Homeobox Protein 1Mob1 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmIt Is Cytoplasmic |
| Alternative Antibody Names | Anti-Homeodomain-Only Protein antibodyAnti-Homeobox-Only Protein antibodyAnti-Odd Homeobox Protein 1 antibodyAnti-Mob1 antibodyAnti-Hopx antibodyAnti-Hod antibodyAnti-Hop antibodyAnti-Ob1 antibody |
Information sourced from Uniprot.org
