Anti-HOPX antibody [R06-4F8] (STJA0034432)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein of mouse HOPX
General Information
| Short Description | Rabbit monoclonal anti-HOPX for use in WB and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IP |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R06-4F8 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | Hopx |
| Gene ID | 74318 |
| Uniprot ID | HOP_MOUSE |
| Immunogen | Recombinant protein of mouse HOPX |
Additional Info
| Tissue Specificity | Expressed in the embryonic and adult heart and in the adult brain, liver, lung, skeletal muscle, intestine and spleen. Throughout embryonic and postnatal development, it is expressed in the myocardium. |
| Function | Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding. |
| Protein Name | Homeodomain-Only ProteinHomeobox-Only ProteinOdd Homeobox Protein 1Mob1 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmIt Is Cytoplasmic |
| Alternative Antibody Names | Anti-Homeodomain-Only Protein antibodyAnti-Homeobox-Only Protein antibodyAnti-Odd Homeobox Protein 1 antibodyAnti-Mob1 antibodyAnti-Hopx antibodyAnti-Hod antibodyAnti-Hop antibodyAnti-Ob1 antibody |
Information sourced from Uniprot.org