Anti-HNRNPC antibody (86-190) (STJ11100595)

Name: Anti-HNRNPC antibody (86-190) (STJ11100595)
SKU: STJ11100595
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11100595

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Short Description	Rabbit polyclonal HNRNPC (86-190) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	HNRNPC
Gene ID	3183
Uniprot ID	HNRPC_HUMAN
Immunogen Region	86-190
Immunogen Sequence	AEPKVNRGKAGVKRSAAEMY GSVTEHPSPSPLLSSSFDLD YDFQRDYYDRMYSYPARVPP PPPIARAVVPSKRQRVSGNT SRRGKSGFNSKSGQRGSSKS GKLKG
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 86-190 of human hnRNP C (NP_112604.2).

Post Translational Modifications	Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide. Sumoylated. Sumoylation reduces affinity for mRNA. Ubiquitinated and degraded after nucleo-cytoplasmic transport by YWHAE.
Function	Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing.
Protein Name	Heterogeneous Nuclear Ribonucleoproteins C1/C2 Hnrnp C1/C2
Database Links	Reactome: R-HSA-4570464 Reactome: R-HSA-72163 Reactome: R-HSA-72203 Reactome: R-HSA-9013418 Reactome: R-HSA-9013422
Cellular Localisation	Nucleus Component Of Ribonucleosomes
Alternative Antibody Names	Anti-Heterogeneous Nuclear Ribonucleoproteins C1/C2 antibody Anti-Hnrnp C1/C2 antibody Anti-HNRNPC antibody Anti-HNRPC antibody

Information sourced from Uniprot.org