| Host: | Goat |
| Applications: | Pep-ELISA/IHC |
| Reactivity: | Human/Mouse/Rat/Dog/Pig/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-HMGA1 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Preliminary experiments gave an approx 50kDa band in Human Testis and Ovary lysates after 0.3µg/ml antibody staining. Please note that currently we cannot find an explanation in the li |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | HMGA1 |
| Gene ID: | 3159 |
| Uniprot ID: | HMGA1_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_665906.1; NP_665908.1; NP_002122.1; NP_665909.1; NP_665912.1; NP_665910.1 |
| Specificity: | This antibody is expected to recognise isoform a (also called HMG-I; NP_665906.1; NP_665908.1) and isoform b (also called HMG-Y; NP_002122.1; NP_665909.1; NP_665910.1; NP_665912.1). |
| Immunogen Sequence: | LASKQEKDGTEK |
| Function | HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. |
| Protein Name | High Mobility Group Protein Hmg-I/Hmg-YHmg-I(YHigh Mobility Group At-Hook Protein 1High Mobility Group Protein A1High Mobility Group Protein R |
| Database Links | Reactome: R-HSA-162592Reactome: R-HSA-164843Reactome: R-HSA-175567Reactome: R-HSA-177539Reactome: R-HSA-180689Reactome: R-HSA-180910Reactome: R-HSA-2559584 |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-High Mobility Group Protein Hmg-I/Hmg-Y antibodyAnti-Hmg-I(Y antibodyAnti-High Mobility Group At-Hook Protein 1 antibodyAnti-High Mobility Group Protein A1 antibodyAnti-High Mobility Group Protein R antibodyAnti-HMGA1 antibodyAnti-HMGIY antibody |
Information sourced from Uniprot.org
