Anti-HJV/Hemojuvelin antibody [SAA1409] (STJA0027752)

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STJA0027752-100
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Short Description :Mouse monoclonal Hemojuvelin antibody for use in FC in human and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications:FC
Host:Mouse
Reactivity:Human/Rat
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :SAA1409
Isotype:IgG2ak
Conjugation:Unconjugated
Concentration:1 mg/ml
Purification:Protein A/G purified from cell culture supernatant.
Formulation:0.01M PBS, pH 7.4, 0.09% Sodium azide.
Storage Instruction:Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol:HJV
Gene ID:148738
Uniprot ID:RGMC_HUMAN
Post Translational Modifications Autocatalytically cleaved at low pH.the two chains remain linked via two disulfide bonds. Also proteolytically processed by TMPRSS6, several fragments being released in the extracellular space.regulates HJV activity in BMP signaling and thefore iron homeostasis.
Function Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.
Protein Name Hemojuvelin
Hemochromatosis Type 2 Protein
Hemojuvelin Bmp Coreceptor
Rgm Domain Family Member C
Database Links Reactome: R-HSA-373752
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Also Released In The Extracellular Space
Alternative Antibody Names Anti-Hemojuvelin antibody
Anti-Hemochromatosis Type 2 Protein antibody
Anti-Hemojuvelin Bmp Coreceptor antibody
Anti-Rgm Domain Family Member C antibody
Anti-HJV antibody
Anti-HFE2 antibody
Anti-RGMC antibody

Information sourced from Uniprot.org

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