| Post Translational Modifications | H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter. Citrullination at Arg-55 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. |
| Function | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. |
| Protein Name | Histone H1.3Histone H1cHistone H1s-2 |
| Database Links | Reactome: R-HSA-140342Reactome: R-HSA-2559584 |
| Cellular Localisation | NucleusChromosomeMore Commonly Found In EuchromatinIs Associated With Inactive Chromatin |
| Alternative Antibody Names | Anti-Histone H1.3 antibodyAnti-Histone H1c antibodyAnti-Histone H1s-2 antibodyAnti-H1-3 antibodyAnti-H1F3 antibodyAnti-HIST1H1D antibody |
Information sourced from Uniprot.org
