Anti-HIP-55/SH3P7 antibody (N-Term) (STJ70176)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-HIP-55/SH3P7 (N-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 55kDa band observed in lysates of Human Peripheral Blood Mononucleocytes (calculated MW of 48.3kDa according to NP_054782.2). Recommended concentration: 0.03-0.1µg/ml. Primary i |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | DBNL |
| Gene ID | 28988 |
| Uniprot ID | DBNL_HUMAN |
| Accession Number | NP_054782.2; NP_001014436.1; NP_001116428.1 |
| Immunogen Region | N-Term |
| Immunogen Sequence | AANLSRNGPALQE |
| Specificity | This antibody is expected to recognise all reported isoforms (NP_054782.2; NP_001014436.1; NP_001116428.1) |
Additional Info
| Function | Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. |
| Protein Name | Drebrin-Like ProteinCervical Sh3p7Cervical Mucin-Associated ProteinDrebrin-FHpk1-Interacting Protein Of 55 KdaHip-55Sh3 Domain-Containing Protein 7 |
| Database Links | Reactome: R-HSA-264870Reactome: R-HSA-6794361Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionLamellipodiumRuffleCell CortexCytosolSynapsePerikaryonNeuron ProjectionCell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmic VesicleClathrin-Coated Vesicle MembraneGolgi Apparatus MembranePodosomeEarly EndosomeDendritePostsynaptic DensityAssociates With Lamellipodial Actin And Membrane RufflesColocalizes With Actin And Cortactin At Podosome Dots And Podosome Rosettes |
| Alternative Antibody Names | Anti-Drebrin-Like Protein antibodyAnti-Cervical Sh3p7 antibodyAnti-Cervical Mucin-Associated Protein antibodyAnti-Drebrin-F antibodyAnti-Hpk1-Interacting Protein Of 55 Kda antibodyAnti-Hip-55 antibodyAnti-Sh3 Domain-Containing Protein 7 antibodyAnti-DBNL antibodyAnti-CMAP antibodyAnti-SH3P7 antibodyAnti-PP5423 antibody |
Information sourced from Uniprot.org