| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HINT1 (1-126) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HINT1 |
| Gene ID: |
3094 |
| Uniprot ID: |
HINT1_HUMAN |
| Immunogen Region: |
1-126 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-126 of human HINT1 (NP_005331.1). |
| Immunogen Sequence: |
MADEIAKAQVARPGGDTIFG KIIRKEIPAKIIFEDDRCLA FHDISPQAPTHFLVIPKKHI SQISVAEDDDESLLGHLMIV GKKCAADLGLNKGYRMVVNE GSDGGQSVYHVHLHVLGGRQ MHWPPG |
| Tissue Specificity | Widely expressed. |
| Function | Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2. Hydrolyzes adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Hydrolyzes 3-indolepropionic acyl-adenylate, tryptamine adenosine phosphoramidate monoester and other fluorogenic purine nucleoside tryptamine phosphoramidates in vitro. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. Also exhibits SUMO-specific isopeptidase activity, deconjugating SUMO1 from RGS17. Deconjugates SUMO1 from RANGAP1. |
| Protein Name | Adenosine 5'-Monophosphoramidase Hint1Desumoylating Isopeptidase Hint1Histidine Triad Nucleotide-Binding Protein 1Protein Kinase C Inhibitor 1Protein Kinase C-Interacting Protein 1Pkci-1 |
| Cellular Localisation | CytoplasmNucleusInteraction With Cdk7 Leads To A More Nuclear Localization |
| Alternative Antibody Names | Anti-Adenosine 5'-Monophosphoramidase Hint1 antibodyAnti-Desumoylating Isopeptidase Hint1 antibodyAnti-Histidine Triad Nucleotide-Binding Protein 1 antibodyAnti-Protein Kinase C Inhibitor 1 antibodyAnti-Protein Kinase C-Interacting Protein 1 antibodyAnti-Pkci-1 antibodyAnti-HINT1 antibodyAnti-HINT antibodyAnti-PKCI1 antibodyAnti-PRKCNH1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
