Anti-HHV8 antibody [13B10] (STJ16101821)

SKU:
STJ16101821-1

£986.50
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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Herpesvirus 8 is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: 13B10
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Tissue culture supernatant with sodium azide
Concentration: >=35 mg/L
Dilution Range: IHC-P 1:50
Storage Instruction: Store at 2-8°C upon receipt.
Immunogen: Prokaryotic recombinant protein corresponding to a portion of the C-terminus of the latent nuclear antigen-1 molecule of HHV8.
Background Human herpesvirus type 8 (HHV8) , is the proposed etiological agent of Kaposi s sarcoma (KS). It is reported that HHV8 has been demonstrated in KS tissues by immunohistochemistry,  in situ PCR and also in situ hybridization. HHV8 encodes a latent nuclear antigen (LNA) which is the product of the viral gene ORF73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product which may be related to its oncogenic activity. HHV8 has been reported to be expressed in multicentric Castleman s disease (MCD) and in angioimmunoblastic lymphadenopathies. The localization of HHV8 in subcapsular spindle cell proliferations, which is where early intranodal KS begins, and endothelial cells in Castleman s disease may explain the link between intranodal KS and MCD. In MCD, HHV8 is reported to be expressed in mantle zone large immunoblastic B cells.

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance