| Host: | Mouse |
| Applications: | IHC-P |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Herpesvirus 8 is suitable for use in Immunohistochemistry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 13B10 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Tissue culture supernatant with sodium azide |
| Concentration: | >=35 mg/L |
| Dilution Range: | IHC-P 1:50 |
| Storage Instruction: | Store at 2-8°C upon receipt. |
| Immunogen: | Prokaryotic recombinant protein corresponding to a portion of the C-terminus of the latent nuclear antigen-1 molecule of HHV8. |
| Background | Human herpesvirus type 8 (HHV8) , is the proposed etiological agent of Kaposi s sarcoma (KS). It is reported that HHV8 has been demonstrated in KS tissues by immunohistochemistry, in situ PCR and also in situ hybridization. HHV8 encodes a latent nuclear antigen (LNA) which is the product of the viral gene ORF73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product which may be related to its oncogenic activity. HHV8 has been reported to be expressed in multicentric Castleman s disease (MCD) and in angioimmunoblastic lymphadenopathies. The localization of HHV8 in subcapsular spindle cell proliferations, which is where early intranodal KS begins, and endothelial cells in Castleman s disease may explain the link between intranodal KS and MCD. In MCD, HHV8 is reported to be expressed in mantle zone large immunoblastic B cells. |
Information sourced from Uniprot.org
![Anti-HHV-8 antibody [13B10] (STJ16100377)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/149094/346712/STJ16100377_1__02867.1681998799.jpg?c=1 "Anti-HHV-8 antibody [13B10] (STJ16100377)")
