![Anti-HGAL antibody [MRQ-49] (STJ16100445)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149162/346786/STJ16100445_1__63279.1681998887.jpg?c=1 "Anti-HGAL antibody [MRQ-49] (STJ16100445)")
![Anti-HGAL antibody [MRQ-49] (STJ16100445)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149162/346787/STJ16100445_2__22139.1681998888.jpg?c=1 "Anti-HGAL antibody [MRQ-49] (STJ16100445)")
![Anti-HGAL antibody [MRQ-49] (STJ16100445)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149162/346786/STJ16100445_1__63279.1681998887.jpg?c=1 "Anti-HGAL antibody [MRQ-49] (STJ16100445)")
| Host: | Mouse |
| Applications: | IHC-P |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-HGAL is suitable for use in Immunohistochemistry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | MRQ-49 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2ak |
| Formulation: | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Dilution Range: | IHC 1:100 – 1:500 |
| Storage Instruction: | Store at 2-8°C upon receipt. |
| Gene Symbol: | GCSAM |
| Gene ID: | 257144 |
| Uniprot ID: | GCSAM_HUMAN |
| Tissue Specificity | Expressed in diffuse large B-cell lymphoma (DLBCL) and several germinal center (GC)-like lymphoma cell lines (at protein level). Highly expressed in normal GC lymphocytes and GC-derived malignancies. Expressed in thymus and spleen. |
| Post Translational Modifications | Phosphorylation on tyrosine residues can be induced by IL6. Phosphorylation is mediated by LYN. Targeted by the ubiquitin E3 ligase subunit FBXO10 to mediate its ubiquitination and degradation. |
| Function | Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. |
| Protein Name | Germinal Center-Associated Signaling And Motility Protein Germinal Center B-Cell-Expressed Transcript 2 Protein Germinal Center-Associated Lymphoma Protein Hgal |
| Cellular Localisation | Cytoplasm Cell Membrane It Relocalizes From The Cytoplasm To Podosome-Like Structures Upon Cell Treatment With Il6 |
| Alternative Antibody Names | Anti-Germinal Center-Associated Signaling And Motility Protein antibody Anti-Germinal Center B-Cell-Expressed Transcript 2 Protein antibody Anti-Germinal Center-Associated Lymphoma Protein antibody Anti-Hgal antibody Anti-GCSAM antibody Anti-GAL antibody Anti-GCET2 antibody |
Information sourced from Uniprot.org