• Anti-HGAL antibody [MRQ-49] (STJ16100445)
  • Anti-HGAL antibody [MRQ-49] (STJ16100445)

Anti-HGAL antibody [MRQ-49] (STJ16100445)

SKU:
STJ16100445

£826.50 - £1,380.50
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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-HGAL is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: MRQ-49
Conjugation: Unconjugated
Isotype: IgG2ak
Formulation: Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Dilution Range: IHC 1:100 – 1:500
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: GCSAM
Gene ID: 257144
Uniprot ID: GCSAM_HUMAN
Tissue Specificity Expressed in diffuse large B-cell lymphoma (DLBCL) and several germinal center (GC)-like lymphoma cell lines (at protein level). Highly expressed in normal GC lymphocytes and GC-derived malignancies. Expressed in thymus and spleen.
Post Translational Modifications Phosphorylation on tyrosine residues can be induced by IL6. Phosphorylation is mediated by LYN. Targeted by the ubiquitin E3 ligase subunit FBXO10 to mediate its ubiquitination and degradation.
Function Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.
Protein Name Germinal Center-Associated Signaling And Motility Protein
Germinal Center B-Cell-Expressed Transcript 2 Protein
Germinal Center-Associated Lymphoma Protein
Hgal
Cellular Localisation Cytoplasm
Cell Membrane
It Relocalizes From The Cytoplasm To Podosome-Like Structures Upon Cell Treatment With Il6
Alternative Antibody Names Anti-Germinal Center-Associated Signaling And Motility Protein antibody
Anti-Germinal Center B-Cell-Expressed Transcript 2 Protein antibody
Anti-Germinal Center-Associated Lymphoma Protein antibody
Anti-Hgal antibody
Anti-GCSAM antibody
Anti-GAL antibody
Anti-GCET2 antibody

Information sourced from Uniprot.org

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