Anti-HFE antibody (249-348) [S4MR] (STJ11102724)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal HFE (249-348) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S4MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HFE |
| Gene ID | 3077 |
| Uniprot ID | HFE_HUMAN |
| Immunogen Region | 249-348 |
| Immunogen Sequence | KEFEPKDVLPNGDGTYQGWI TLAVPPGEEQRYTCQVEHPG LDQPLIVIWEPSPSGTLVIG VISGIAVFVVILFIGILFII LRKRQGSRGAMGHYVLAERE |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 249-348 of human HFE (Q30201). |
Additional Info
| Tissue Specificity | Expressed in all tissues tested except brain. |
| Function | Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. |
| Protein Name | Hereditary Hemochromatosis ProteinHla-H |
| Database Links | Reactome: R-HSA-917977 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Hereditary Hemochromatosis Protein antibodyAnti-Hla-H antibodyAnti-HFE antibodyAnti-HLAH antibody |
Information sourced from Uniprot.org