| Tissue Specificity | Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle. |
| Function | Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis. |
| Protein Name | Hexokinase-2Hexokinase Type IiHk IiHexokinase-BMuscle Form Hexokinase |
| Database Links | Reactome: R-HSA-70171 |
| Cellular Localisation | Mitochondrion Outer MembranePeripheral Membrane ProteinCytoplasmCytosolThe Mitochondrial-Binding Peptide (Mbp) Region Promotes Association With The Mitochondrial Outer MembraneThe Interaction With The Mitochondrial Outer Membrane Via The Mitochondrial-Binding Peptide (Mbp) Region Promotes Higher Stability Of The ProteinRelease From The Mitochondrial Outer Membrane Into The Cytosol Induces Permeability Transition Pore (Ptp) Opening And Apoptosis |
| Alternative Antibody Names | Anti-Hexokinase-2 antibodyAnti-Hexokinase Type Ii antibodyAnti-Hk Ii antibodyAnti-Hexokinase-B antibodyAnti-Muscle Form Hexokinase antibodyAnti-HK2 antibody |
Information sourced from Uniprot.org
![Anti-Hexokinase II antibody [SM0415] (STJA0010415)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/180312/403965/STJA0010415_1__79398.1738950934.png?c=1 "Anti-Hexokinase II antibody [SM0415] (STJA0010415)")