| Host: |
Rabbit |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Beta-hexosaminidase subunit beta (481-530 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HEXB |
| Gene ID: |
3074 |
| Uniprot ID: |
HEXB_HUMAN |
| Immunogen Region: |
481-530 aa |
| Specificity: |
Hexb Polyclonal Antibody detects endogenous levels of Hexb protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human HEXB at the amino acid range 481-530 |
| Function | Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida. |
| Protein Name | Beta-Hexosaminidase Subunit BetaBeta-N-Acetylhexosaminidase Subunit BetaHexosaminidase Subunit BCervical Cancer Proto-Oncogene 7 ProteinHcc-7N-Acetyl-Beta-Glucosaminidase Subunit Beta Cleaved Into - Beta-Hexosaminidase Subunit Beta Chain B - Beta-Hexosaminidase Subunit Beta Chain A |
| Database Links | Reactome: R-HSA-1660662Reactome: R-HSA-2022857Reactome: R-HSA-2024101Reactome: R-HSA-2160916Reactome: R-HSA-3656248Reactome: R-HSA-6798695 |
| Cellular Localisation | LysosomeCytoplasmic VesicleSecretory VesicleCortical Granule |
| Alternative Antibody Names | Anti-Beta-Hexosaminidase Subunit Beta antibodyAnti-Beta-N-Acetylhexosaminidase Subunit Beta antibodyAnti-Hexosaminidase Subunit B antibodyAnti-Cervical Cancer Proto-Oncogene 7 Protein antibodyAnti-Hcc-7 antibodyAnti-N-Acetyl-Beta-Glucosaminidase Subunit Beta Cleaved Into - Beta-Hexosaminidase Subunit Beta Chain B - Beta-Hexosaminidase Subunit Beta Chain A antibodyAnti-HEXB antibodyAnti-HCC7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
