| Host: |
Rabbit |
| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
HEXB |
| Gene ID: |
3074 |
| Uniprot ID: |
HEXB_HUMAN |
| Immunogen Region: |
277-556 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 277-556 of human HEXB (NP_000512.1). |
| Immunogen Sequence: |
YARLRGIRVLPEFDTPGHTL SWGKGQKDLLTPCYSRQNKL DSFGPINPTLNTTYSFLTTF FKEISEVFPDQFIHLGGDEV EFKCWESNPKIQDFMRQKGF GTDFKKLESFYIQKVLDIIA TINKGSIVWQEVFDDKAKLA PGTIVEVWKDSAYPEELSRV TASGFPVILSAPWYLDLISY GQDWRKYYKVEPLDFGGTQK QKQLFIGGEACLWGEYVDAT NLTPRLWPRASAVGERLWS |
| Post Translational Modifications | N-linked glycans at Asn-142 and Asn-190 consist of Man(3)-GlcNAc(2) and Man(5 to 7)-GlcNAc(2), respectively. The beta-A and beta-B chains are produced by proteolytic processing of the precursor beta chain. |
| Function | Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida. |
| Protein Name | Beta-Hexosaminidase Subunit BetaBeta-N-Acetylhexosaminidase Subunit BetaHexosaminidase Subunit BCervical Cancer Proto-Oncogene 7 ProteinHcc-7N-Acetyl-Beta-Glucosaminidase Subunit Beta Cleaved Into - Beta-Hexosaminidase Subunit Beta Chain B - Beta-Hexosaminidase Subunit Beta Chain A |
| Database Links | Reactome: R-HSA-2022857Reactome: R-HSA-2024101Reactome: R-HSA-2160916Reactome: R-HSA-3656248Reactome: R-HSA-6798695Reactome: R-HSA-9840310 |
| Cellular Localisation | LysosomeCytoplasmic VesicleSecretory VesicleCortical Granule |
| Alternative Antibody Names | Anti-Beta-Hexosaminidase Subunit Beta antibodyAnti-Beta-N-Acetylhexosaminidase Subunit Beta antibodyAnti-Hexosaminidase Subunit B antibodyAnti-Cervical Cancer Proto-Oncogene 7 Protein antibodyAnti-Hcc-7 antibodyAnti-N-Acetyl-Beta-Glucosaminidase Subunit Beta Cleaved Into - Beta-Hexosaminidase Subunit Beta Chain B - Beta-Hexosaminidase Subunit Beta Chain A antibodyAnti-HEXB antibodyAnti-HCC7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
